She was discovered by an agent in acting class; subsequently, Blair signed with her.
She starred as a suicidal bank teller taken hostage during a bank robbery, who tries to persuade her captors to kill her.
The film received a limited release in September 2001, in New York and Los Angeles.
She next starred as a college student having an affair with her professor in the controversial independent drama Storytelling, alongside Leo Fitzpatrick.
In 1997, she made her first appearance on a mainstream feature film, the Kevin Kline comedy In & Out.
Blair auditioned six times for the role and remained several weeks on the set, but most of her scenes were cut from the final screened edition.
She subsequently appeared in several independent and short productions, including Debutante, opposite Josh Hartnett.